The need-to-know information for TXA:TXA
Pearls and fun nuggets
1. Well done, Japan 👍 Tranexamic acid was first synthesized in 1962 by Japanese researchers Shosuke and Utako Okamoto. It has been included in the WHO list of essential medicines. TXA is inexpensive and treatment would be considered highly cost effective in high, middle and low income countries.
2. Has your mom had TXA? 🙋 Tranexamic acid is often used after delivery to reduce bleeding, often with oxytocin. Death due to postpartum bleeding was reduced in women receiving tranexamic acid.
3. TXA for bleeding disorders? 😶 There is not enough evidence to support the routine use of tranexamic acid to prevent bleeding in people with blood cancers. However, there are several trials that are currently assessing this use of tranexamic acid. For people with inherited bleeding disorders (e.g. von Willebrand’s disease), tranexamic acid is often given. It has also been recommended for people with acquired bleeding disorders (e.g., directly acting oral anticoagulants (DOACs)) to treat serious bleeding.
4. TXA may soon not require a prescription 🙊 In March 2011 the status of tranexamic acid for treatment of heavy menstrual bleeding was changed in the UK, from PoM (Prescription only Medicines) to P (Pharmacy Medicines) and became available over the counter in UK pharmacies under the brand names of Cyklo-F and Femstrual, initially exclusively for Boots pharmacy, which has sparked some discussion about availability.
“This tranexamic acid medication reduced my menstrual bleeding about 50 percent and made it so I could function and go to work. It started working in a little less than 24 hours.”
“I have a hereditary vascular disorder called HHT (Hereditary hemorrhagic telangiectasia). I have had daily horrible nose bleeds, to the point of needing frequent transfusions. Had cauterization and laser treatments, which only helped for a few weeks. I have been on the medication for 2 months now, and have had only 2 “gushers”. I hope this improvement continues.”
“I have suffered year with periods so bad they would make me faint with pain. I eventually plucked up courage to go to dr and had a emergency lap which showed no endo . I was put on tranexamic acid and “ it changed my life” I also use buscopan for the cramping and bloating and together I can go about my daily business. It almost stops my bleeding. I bleed for 3 days not 9-10. Great little drug”