The need-to-know information for Ibuprofen (Motrin/Advil)



Pearls and Fun Nuggets

1. Ibuprofen was discovered while trying to find a safer alternative to Aspirinūüí䬆 It was derived from propionic acid¬†by the¬†research¬†arm of¬†Boots Group¬†during the 1960s.[55][10][56]¬†It was discovered by a team led by¬†Stewart Adams¬†and the patent application was filed in 1961.[10]¬†Adams initially tested the drug as treatment for his¬†hangover.[57]

2. Don’t take it with alcohol ūü漬† Drinking alcohol when taking ibuprofen may increase the risk of stomach bleeding.[35]

3. Too much ibuprofen could be bad for your heart ūüíĒ Along with several other NSAIDs, chronic ibuprofen use has been found correlated with risk of hypertension[25]¬†and¬†myocardial infarction¬†(heart attack),[26]¬†particularly among those treated chronically using high doses.

4. Ibuprofen could interfere with Aspirin ūüöę According to the Food and Drug Administration¬†(FDA), “ibuprofen can interfere with the¬†antiplatelet¬†effect of low-dose aspirin, potentially rendering aspirin less effective when used for cardioprotection and¬†stroke¬†prevention.” Allowing sufficient time between doses of ibuprofen and immediate-release (IR) aspirin can avoid this problem.

5. Ibuprofen can be toxic ūüėĪ Toxic effects are unlikely at doses below 100¬†mg/kg, but can be severe above 400¬†mg/kg (around 150 tablets of 200¬†mg units for an average man);[40]¬†however, large doses do not indicate the clinical course is likely to be lethal.[41]¬†A precise¬†lethal dose¬†is difficult to determine, as it may vary with age, weight, and concomitant conditions of the individual person.

Patient Perspectives

“I took 600 MG of this medication for a mild to moderate knee sprain, and it made it tolerable to bear weight. It reduces inflammation, which is good for minor injuries. I would highly recommend this for short term use, as it’s over the counter and not sedating. It works pretty fast, too.”


“I get varying types of headaches; migraine, stress, tension, sinus. Ibuprofen works most of the time but tends to take a while to work. And if taken on an empty stomach, will make you nauseous. I recommend using the gel-caps, as they seem to be softer on the stomach.”


“I have severe hip flexor pain, and my doctor recommended this. It did nothing for it. “


Brandon Simpson, PA-C
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